Members' NAVLE study guide

Feline Hypothyroidism

1,612 words 7 min read 1 figure Reviewed November 14, 2026

Hypothyroidism is a shortage of thyroid hormone (T4 and T3). In cats it behaves very differently from dogs: spontaneous disease is rare, and the usual cause is treatment of hyperthyroidism. Its main clinical importance is that it can worsen azotemia in cats that have been treated for hyperthyroidism. For the other side of the coin, see the feline hyperthyroidism guide.

Key facts

Hypothyroidism at a glance
  • Species and system: cat, endocrine (thyroid).
  • Cause: iatrogenic after radioiodine, bilateral thyroidectomy or antithyroid drugs (the most common form); congenital (dyshormonogenesis or dysgenesis); rare spontaneous adult disease.
  • Adult signs: often mild or absent; lethargy, dull mentation, seborrhea sicca, hypothermia, reduced appetite.
  • Kitten signs: disproportionate dwarfism, severe lethargy, mental dullness, constipation, bradycardia.
  • Zoonotic or reportable: no.

What's inside

13 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Hypothyroidism and kidney disease
  7. Differential diagnoses
  8. Treatment and management
  9. Prognosis
  10. Working through a case
  11. Quick review
  12. Test yourself
  13. References
The full guide also has 5 tables, 1 figure, 3 self-test questions and 7 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Hypothyroidism on the NavleExam blog.

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Feline · Endocrine