Members' NAVLE study guide

Feline Acromegaly (Hypersomatotropism)

1,596 words 7 min read Reviewed November 12, 2026

Feline acromegaly (hypersomatotropism) is chronic growth hormone (GH) excess, almost always from a slow-growing GH-secreting pituitary adenoma. It matters because it is a leading cause of insulin-resistant diabetes in cats and is easy to miss.

Key facts

Acromegaly at a glance
  • Species and system: cat; endocrine (anterior pituitary).
  • Cause: GH-secreting adenoma of the pars distalis; rarely hyperplasia.
  • Signalment: older cats (8 to 14 years), apparently more common in males.
  • Classic presentation: a diabetic cat needing ever larger insulin doses and gaining weight, often with a broad face, large paws, organomegaly or stridor.
  • Prevalence: about 25% of diabetic cats screened in a large UK study (24.8%).
  • Zoonotic or reportable: no.

What's inside

13 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Working through the case
  9. Prevention, control and public health
  10. Prognosis
  11. Quick review
  12. Test yourself
  13. References
The full guide also has 5 tables, 3 self-test questions and 9 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Acromegaly on the NavleExam blog.