Members' NAVLE study guide

Feline Diabetes Mellitus: Diagnosis, Insulin and Remission | NAVLE

1,591 words 8 min read Reviewed November 13, 2026

Diabetes mellitus is one of the commonest endocrine diseases of middle-aged to older cats. Most feline cases resemble human type 2 diabetes, which is why cats, unlike dogs, can go into remission. Success depends on the right insulin, a low-carbohydrate diet, home monitoring and a client who understands the plan.

Key facts

Diabetes mellitus at a glance
  • Species and system: cat; endocrine pancreas.
  • Cause: relative or absolute insulin deficiency; islet amyloid (from islet amyloid polypeptide) with beta-cell loss and insulin resistance from obesity, drugs and other disease.
  • Classic presentation: polyuria, polydipsia, polyphagia and weight loss; sometimes a plantigrade stance from neuropathy.
  • Diagnosis: persistent hyperglycaemia plus glucosuria; fructosamine helps exclude stress hyperglycaemia.
  • Treatment: insulin plus a high-protein, low-carbohydrate diet; SGLT2 inhibitors for selected new cases.
  • Zoonotic or reportable: no.

What's inside

12 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Prevention, control and public health
  9. Prognosis
  10. Quick review
  11. Test yourself
  12. References
The full guide also has 5 tables, 3 self-test questions and 9 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Diabetes mellitus on the NavleExam blog.

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