Members' NAVLE study guide

Feline Claw Disease and Toenail Avulsion | NAVLE Guide

2,188 words 9 min read 1 figure Reviewed November 13, 2026

Claw disease is uncommon in cats but very painful, because the claw is built directly onto bone. Most cases come down to one question: is one digit affected, which usually means trauma, or are many digits affected, which points to a systemic disease such as pemphigus foliaceus or metastatic lung cancer?

Key facts

Disease of claws (including toenail avulsion) at a glance
  • Species and system: cat, integumentary (claw, claw fold and third phalanx).
  • Single claw: usually trauma (avulsion, foreign body) or a local infection.
  • Several claws or feet: think pemphigus foliaceus, lung-digit syndrome, dermatophytosis or immunosuppression.
  • Classic pemphigus foliaceus sign: sterile paronychia with thick caseous material at the claw folds, with face and pinna crusting.
  • Classic lung-digit syndrome: older cat, swollen weight-bearing digit, nail loss, no respiratory signs.
  • Not zoonotic except for dermatophytes, which are a possible cause.

What's inside

13 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Anatomy that explains the signs
  4. Toenail avulsion
  5. Paronychia
  6. Pemphigus foliaceus and the claw
  7. Digital neoplasia and lung-digit syndrome
  8. Clinical decision framework
  9. Prevention
  10. Prognosis
  11. Quick review
  12. Test yourself
  13. References
The full guide also has 4 tables, 1 figure, 3 self-test questions and 8 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Disease of claws (including toenail avulsion) on the NavleExam blog.

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Feline · Integumentary