Members' NAVLE study guide

Potomac Horse Fever (N. risticii)

1,482 words 6 min read 1 figure Reviewed November 12, 2026

Potomac horse fever (PHF) is an acute enterocolitis of horses of all ages caused by Neorickettsia risticii. It causes fever, depression, diarrhea and laminitis, and in pregnant mares abortion. It occurs in spring, summer and early fall, mostly on pastures bordering creeks or rivers, and responds to oxytetracycline if treated early.

Key facts

Potomac horse fever (Neorickettsia risticii) at a glance
  • Species and system: horse; small and large intestine.
  • Cause: Neorickettsia risticii, a gram-negative obligate intracellular bacterium with tropism for monocytes.
  • Transmission: a trematode vector; likely ingestion of hatched aquatic insects carrying the agent. Sick horses are not contagious.
  • Classic presentation: mild depression and anorexia, fever, then diarrhea in about 60% of cases, in a horse on pasture near water in warm months.
  • Key complication: laminitis in 20 to 30% of cases.
  • Zoonotic: no known zoonotic risk (MSD).

What's inside

13 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Working through a case
  9. Prevention, control and public health
  10. Prognosis
  11. Quick review
  12. Test yourself
  13. References
The full guide also has 5 tables, 1 figure, 3 self-test questions and 3 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Potomac horse fever (Neorickettsia risticii) on the NavleExam blog.

More guides

Equine · Gastrointestinal/Digestive