Members' NAVLE study guide

Equine Acute Colitis: Salmonella and Clostridia | NAVLE

1,711 words 8 min read 1 figure Reviewed November 12, 2026

Acute colitis in the adult horse is an emergency: profuse diarrhea, dehydration, electrolyte loss and endotoxemia that can progress to shock and death within hours to days. Salmonella enterica, Clostridioides difficile and Clostridium perfringens are the main infectious bacterial causes, but the cause often goes unconfirmed. Treatment is supportive and starts before test results return, together with isolation, because several causes are contagious and Salmonella is zoonotic.

Key facts

Acute colitis-diarrhea (Salmonella, Clostridium) at a glance
  • Species and system: horse; large intestine (cecum and colon).
  • Causes: Salmonella, C. difficile, C. perfringens, Potomac horse fever, equine coronavirus and others; clinically they cannot be told apart (MSD).
  • Risk factors: surgery, transport, feed change, concurrent GI disease, broad-spectrum antimicrobials, stress.
  • Classic presentation: fever, depression, then profuse fluid, foul-smelling diarrhea with neutropenia and dehydration.
  • Zoonotic: yes for Salmonella; use strict biosecurity and isolate affected horses.
  • Cornerstone of treatment: large volumes of IV polyionic fluids with electrolytes.

What's inside

12 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Prevention, control and public health
  9. Prognosis
  10. Quick review
  11. Test yourself
  12. References
The full guide also has 5 tables, 1 figure, 3 self-test questions and 6 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Acute colitis-diarrhea (Salmonella, Clostridium) on the NavleExam blog.