Members' NAVLE study guide

Feline Insecticide Toxicity: Permethrin and More | NAVLE

1,492 words 8 min read Reviewed November 14, 2026

Insecticide poisoning in cats is usually accidental: a dog product applied to a cat, a cat grooming a recently treated dog, or a chewed tick collar. Three groups matter for the NAVLE: pyrethrins and pyrethroids (permethrin is the classic), organophosphates and carbamates, and amitraz. Each has a different clinical picture and a different antidote.

Key facts

Insecticide toxicity at a glance
  • Species and system: cat; neuromuscular and multisystemic toxicology.
  • Pyrethroids: cats appear more sensitive than other pets (MSD); permethrin dog products are the classic cause. Tremors, seizures, hypersalivation.
  • Organophosphates and carbamates: acetylcholinesterase inhibition causes a cholinergic crisis; atropine, and pralidoxime for organophosphates.
  • Amitraz: an alpha-2 agonist, not recommended in cats; sedation, bradycardia, mydriasis, hyperglycemia; treat with atipamezole or yohimbine.
  • Handling: staff and owners should wear gloves when bathing a contaminated cat.

What's inside

10 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Pyrethrin and pyrethroid toxicosis
  4. Organophosphate and carbamate toxicosis
  5. Amitraz toxicosis
  6. Differential diagnoses
  7. Prevention and prognosis
  8. Quick review
  9. Test yourself
  10. References
The full guide also has 4 tables, 3 self-test questions and 8 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Insecticide toxicity on the NavleExam blog.

More guides

Feline · Multisystemic