Members' NAVLE study guide

Feline Cytauxzoonosis (Bobcat Fever)

1,614 words 7 min read 1 figure Reviewed November 13, 2026

Cytauxzoon felis is a tick-borne protozoan that causes a rapidly progressive, often fatal illness in domestic cats. It is nicknamed bobcat fever because the bobcat is the natural reservoir. It is a favorite exam topic because the history (outdoor cat, spring or summer, lone star tick area), the high fever and the treatment pair are all distinctive.

Key facts

Cytauxzoonosis at a glance
  • Species and system: cat; multisystemic (blood, vessels, liver, spleen, lungs).
  • Cause: Cytauxzoon felis, an apicomplexan parasite; the lone star tick (Amblyomma americanum) is the main vector. The American dog tick transmitted it experimentally and is a less effective vector.
  • Reservoir: bobcats (Lynx rufus), usually subclinical with chronic parasitemia; the domestic cat is considered an aberrant host.
  • Season and risk: usually diagnosed April through September; highest risk for cats near wooded, unmanaged habitat.
  • Classic presentation: depression, anorexia, fever, dehydration and rapid decline about 5 to 14 days after the tick bite.
  • Treatment: atovaquone plus azithromycin with intensive supportive care.
  • Zoonotic or reportable: no.

What's inside

13 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Prevention, control and public health
  9. Working up a suspect case
  10. Prognosis
  11. Quick review
  12. Test yourself
  13. References
The full guide also has 4 tables, 1 figure, 3 self-test questions and 4 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Cytauxzoonosis on the NavleExam blog.

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