Members' NAVLE study guide

Feline Hypokalemia and Polymyopathy | NAVLE Guide

1,416 words 7 min read Reviewed November 14, 2026

Hypokalemia is a serum potassium concentration below the reference interval. In cats it is a common cause of generalized muscle weakness and neck ventroflexion, usually from chronic kidney disease (CKD) or another condition that causes potassium loss. Replacing it safely is a favourite exam topic because the infusion rate matters.

Key facts

Hypokalemia at a glance
  • Species and system: cat; electrolyte, neuromuscular, renal.
  • Main cause: most cats with hypokalemic polymyopathy have it secondary to CKD with urinary potassium loss (MSD).
  • Other causes: hyperaldosteronism, hyperthyroidism, dietary deficiency, excessive fluids, chronic vomiting or diarrhea, potassium-wasting diuretics, dorzolamide or brinzolamide eye drops.
  • Classic presentation: acute generalized weakness and ventroflexion of the neck.
  • Treatment: oral potassium; IV only up to 0.5 mEq/kg/h in profound cases; treat the cause.
  • Zoonotic: no.

What's inside

12 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Putting it together in practice
  9. Prognosis
  10. Quick review
  11. Test yourself
  12. References
The full guide also has 5 tables, 3 self-test questions and 5 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Hypokalemia on the NavleExam blog.

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