NAVLE Gastrointestinal and Digestive

Porcine Rotavirus Infection Study Guide

Rotavirus infection is one of the most common causes of viral diarrhea in nursing and weaned piglets worldwide.

Overview and Clinical Importance

Rotavirus infection is one of the most common causes of viral diarrhea in nursing and weaned piglets worldwide. The virus belongs to the family Reoviridae and is characterized by its distinctive wheel-like appearance on electron microscopy (Latin rota = wheel). Rotavirus is ubiquitous in swine herds globally, with nearly 100% seroconversion in adult pigs.

Understanding rotavirus is critical for the NAVLE because it represents a high-yield topic in swine medicine, particularly regarding neonatal diarrhea differential diagnosis, pathophysiology of malabsorptive diarrhea, and management of enteric diseases in production animals.

Protein Location Function/Significance
VP4 Outer capsid spike Hemagglutinin; P-type serotype determinant; cell attachment; trypsin-cleaved to VP5* and VP8*
VP6 Inner capsid Group-specific antigen; basis for serogroup classification (A, B, C, etc.)
VP7 Outer capsid surface Glycoprotein; G-type serotype determinant; major neutralizing antigen

Etiology

Virus Classification and Structure

Rotaviruses are non-enveloped, double-stranded RNA viruses approximately 70-100 nm in diameter. The virion consists of a triple-layered icosahedral capsid surrounding 11 segments of dsRNA genome.

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