NAVLE Musculoskeletal

Porcine Mycoplasma hyosynoviae Arthritis – NAVLE Study Guide

Mycoplasma hyosynoviae is a major cause of infectious arthritis in growing-finishing pigs and replacement breeding stock.

Overview and Clinical Importance

Mycoplasma hyosynoviae is a major cause of infectious arthritis in growing-finishing pigs and replacement breeding stock. This ubiquitous organism colonizes the upper respiratory tract and tonsils of pigs, spreading hematogenously to cause a non-suppurative polyarthritis. Understanding this disease is essential for NAVLE preparation as it represents a common differential diagnosis for lameness in swine production.

Unlike Mycoplasma hyorhinis which primarily affects younger pigs (3-10 weeks), M. hyosynoviae targets pigs weighing 35-115 kg (approximately 10-24 weeks of age). This age distinction is a critical point for NAVLE examination questions.

Parameter Details
Age Affected 10-24 weeks (35-115 kg body weight); grower-finisher pigs and gilts most commonly affected
Morbidity Usually low to moderate (1-10%); can reach 50% in naive or immunocompromised populations
Mortality Very low; deaths typically due to secondary complications (starvation, cannibalism)
Reservoir Tonsils and upper respiratory tract of carrier pigs; sows are primary reservoir
Transmission Oronasal route via aerosol, direct contact, or contaminated fomites
Incubation Period 4-10 days from infection to clinical signs

Etiology

Mycoplasma hyosynoviae is a small, cell wall-deficient bacterium belonging to the class Mollicutes. Key characteristics include:

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