Members' NAVLE study guide

Feline Lymphadenopathy and Lymphoma

1,631 words 7 min read 1 figure Reviewed November 15, 2026

Lymphadenopathy means an enlarged lymph node, either one node, a region, or all palpable nodes. In cats the main task is to separate reactive change and infection from neoplasia, because treatment is completely different. Lymphoma is the most important neoplastic cause, but many enlarged nodes are not lymphoma.

Key facts

Lymphoma at a glance
  • Species and system: cat; hemic/lymphatic.
  • Mechanisms: reactive hyperplasia, lymphadenitis (infection or inflammation), or neoplastic infiltration (primary lymphoma or metastasis).
  • Peripheral nodes you can palpate: mandibular, superficial cervical (prescapular), axillary, superficial inguinal and popliteal.
  • Abdominal nodes: usually seen on ultrasound only; jejunal (mesenteric) and medial iliac nodes are the usual ones to assess.
  • First test: fine needle aspirate cytology; test every cat for FeLV and FIV.
  • Zoonotic: some causes are (Sporothrix, Bartonella, Pasteurella-type bite infections, Mycobacterium).

What's inside

12 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Prevention, control and public health
  9. Prognosis
  10. Quick review
  11. Test yourself
  12. References
The full guide also has 6 tables, 1 figure, 3 self-test questions and 7 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Lymphoma on the NavleExam blog.

More guides

Feline · Hemic/Lymphatic