Members' NAVLE study guide

Canine Rabies: Bite, Exposure & DFA Rules

3,252 words 13 min read 3 figures Reviewed November 11, 2026

Rabies is an acute, progressive viral encephalitis that is almost always fatal once neurological signs begin, and every mammal is thought to be susceptible. In the United States the dog-adapted virus variant is gone, yet dogs still catch rabies from wildlife, and every rabid dog is a potential human exposure. That is why the NAVLE treats canine rabies mainly as a public health question: what to do with a dog that bit someone, what to do with a dog that met a rabid animal, and how to get a diagnosis.

Key facts

Rabies (suspected or confirmed) at a glance
  • Species: dog (all mammals susceptible; cats are now the most often reported rabid domestic animal in the US).
  • System: nervous system (encephalomyelitis).
  • Cause: rabies virus, genus Lyssavirus, family Rhabdoviridae; bullet-shaped, enveloped, single-stranded negative-sense RNA virus.
  • Classic presentation: sudden behaviour change progressing to aggression (furious form) or to jaw and throat paralysis with drooling and dysphagia (paralytic form), then ascending paralysis and death.
  • Diagnosis: direct fluorescent antibody (DFA) test on brain tissue after euthanasia; there is no reliable antemortem test in animals.
  • Zoonotic and reportable: yes. Suspect cases and exposures go to the local or state health department.

What's inside

12 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Prevention, control and public health
  9. Prognosis
  10. Quick review
  11. Test yourself
  12. References
The full guide also has 4 tables, 3 figures, 3 self-test questions and 10 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Rabies (suspected or confirmed) on the NavleExam blog.

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