NAVLE Multisystemic

Porcine African Swine Fever Study Guide

African Swine Fever (ASF) is a highly contagious, hemorrhagic viral disease affecting domestic pigs and wild boars with case fatality rates approaching 100% in acute infections.

Overview and Clinical Importance

African Swine Fever (ASF) is a highly contagious, hemorrhagic viral disease affecting domestic pigs and wild boars with case fatality rates approaching 100% in acute infections. Caused by the African Swine Fever Virus (ASFV), the sole member of the family Asfarviridae, ASF represents one of the most devastating threats to global swine production and food security.

ASF is a WOAH-listed reportable disease, meaning all cases must be reported to the World Organisation for Animal Health. Since 2007, ASFV genotype II has spread from Georgia to Europe, Asia, and the Caribbean, causing billions of dollars in economic losses. There is NO commercially available vaccine or treatment, making biosecurity and early detection the primary control measures.

High-YieldASF is NOT zoonotic - it does NOT affect humans. However, humans can mechanically transmit the virus through contaminated clothing, equipment, or by feeding pigs uncooked pork products (swill feeding).
Feature Description
Genome Double-stranded DNA, 170-190 kb
Structure Enveloped, icosahedral symmetry
Genotypes 24 genotypes identified based on p72 gene
Target Cells Monocytes, macrophages (mononuclear phagocytic system)
Key Proteins p72 (major capsid), p30, p54, CD2v (hemadsorption)

Etiology

Viral Characteristics

ASFV is a large, complex, enveloped, double-stranded DNA virus approximately 170-190 kilobases in size. It is the only member of the genus Asfivirus and family Asfarviridae. The virus is classified within the phylum Nucleocytoviricota and shares distant relationships with poxviruses and iridoviruses.

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