NAVLE Multisystemic

Feline Toxoplasmosis Study Guide

Toxoplasmosis is a multisystemic disease caused by the obligate intracellular apicomplexan parasite Toxoplasma gondii. This zoonotic infection is of significant veterinary and public health importance.

Overview and Clinical Importance

Toxoplasmosis is a multisystemic disease caused by the obligate intracellular apicomplexan parasite Toxoplasma gondii. This zoonotic infection is of significant veterinary and public health importance. Felids (domestic cats and wild felids) serve as the only definitive hosts where sexual reproduction occurs, making understanding of feline toxoplasmosis essential for veterinarians.

While infection with T. gondii is common (up to 50% of cats are seropositive), clinical disease is rare and typically occurs in immunocompromised cats (FIV, FeLV, or immunosuppressive therapy) or congenitally infected kittens. Commonly affected organ systems include the CNS, lungs, eyes, liver, and muscles.

High-YieldCats are the ONLY definitive host for T. gondii. They shed oocysts for only 1-3 weeks (usually once in their lifetime) after primary infection. Seropositive cats are NOT a public health risk because they have already shed oocysts and developed immunity.
Risk Factor Clinical Significance
FIV infection Predisposes to acute generalized toxoplasmosis; impaired cell-mediated immunity
FeLV infection Associated with reactivation of latent infection
Cyclosporine therapy Well-documented association; check T. gondii status before starting therapy
Congenital infection Most severe form; kittens develop hepatitis, pneumonia, encephalitis
Organ transplantation Acute disease 3-6 weeks post-renal transplant reported

Etiology and Life Cycle

The Parasite

Toxoplasma gondii is an obligate intracellular protozoan parasite belonging to the phylum Apicomplexa. It has three infectious stages:

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