Members' NAVLE study guide

Feline Metastatic Lung Disease

1,739 words 7 min read 1 figure Reviewed November 15, 2026

Cancer that has spread to the lungs is the usual way a cat's tumour becomes life-threatening, and cats hide it well. They seldom cough, so the first signs may be lethargy, poor appetite or weight loss, and in one unusual syndrome the first sign may be a swollen toe. This guide covers how tumours reach the lung, how to recognise lung-digit syndrome, and how to stage a cat with a malignant tumour.

Key facts

Metastatic lung disease at a glance
  • Species and system: cat, lower respiratory tract (lung parenchyma and pleura).
  • Cause: tumour cells from a distant primary reach the lungs through blood or lymph. The lungs receive the entire cardiac output, so emboli lodge easily.
  • Common primary tumours: mammary adenocarcinoma, osteosarcoma, hemangiosarcoma and oral melanoma (MSD).
  • Classic presentation: non-specific illness, often without cough; pleural effusion and dyspnoea in advanced disease.
  • Special syndrome: lung-digit syndrome, with a lung carcinoma that spreads to the toes.
  • Outlook: metastasis occurs late in a malignant tumour, so the prognosis is poor.

What's inside

13 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Lung-digit syndrome
  5. Clinical signs
  6. Diagnosis
  7. Differential diagnoses
  8. Staging a cat with a malignant tumour
  9. Treatment and management
  10. Prognosis
  11. Quick review
  12. Test yourself
  13. References
The full guide also has 4 tables, 1 figure, 3 self-test questions and 10 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Metastatic lung disease on the NavleExam blog.

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