Members' NAVLE study guide

Feline Mammary Hyperplasia

1,683 words 7 min read 1 figure Reviewed November 15, 2026

Feline mammary hyperplasia, also called fibroadenomatous or fibroepithelial hyperplasia or mammary hypertrophy, is a benign, progesterone-associated overgrowth of mammary tissue. It makes one or more glands swell rapidly, sometimes enormously, and it looks alarming. On the exam it is the benign look-alike of mammary cancer and mastitis.

Key facts

Mammary hyperplasia at a glance
  • Species and system: cat; mammary gland (reproductive system).
  • Cause: progesterone, from the cycle or pregnancy, or from progestin drugs (MSD).
  • Who: usually young sexually intact females after estrus, and cats of either sex on long-term progestins; no breed predisposition (MSD).
  • Classic presentation: sudden swelling of one or more mammary glands, which may be erythematous or ulcerated, in a cat that is not producing milk.
  • Treatment: remove the progesterone source: stop the progestin, give an antiprogestin, or spay (in diestrus).
  • Caution: any feline mammary mass should be treated with concern because most feline mammary tumours are malignant.

What's inside

15 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Prevention, control and public health
  9. Prognosis
  10. Working through a case
  11. Complications to remember
  12. Exam pearls and common errors
  13. Quick review
  14. Test yourself
  15. References
The full guide also has 4 tables, 1 figure, 3 self-test questions and 7 references, available to NAVLE members.

Read the full study guide

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Read the free overview article A shorter, free article on Mammary hyperplasia on the NavleExam blog.

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Feline · Reproductive