Members' NAVLE study guide

Feline Idiopathic Cystitis (FIC)

1,590 words 7 min read Reviewed November 14, 2026

Feline idiopathic cystitis (FIC) is a painful, sterile inflammation of the bladder with no identifiable cause. It is the most common reason for lower urinary tract signs in cats, and it is a diagnosis of exclusion. It matters on the NAVLE because the treatment is mostly environmental, and antibiotics and surgery are common wrong answers.

Key facts

Idiopathic cystitis at a glance
  • Species and system: cat, lower urinary tract.
  • Cause: unknown. Stress, abnormal neurohormonal signalling and the bladder interact (MSD). Newer work frames FIC as a threat-responsive disorder involving the whole cat, with cases sometimes called Pandora syndrome.
  • Frequency: a cause cannot be found in about 55 to 65% of cats with lower urinary tract signs.
  • Classic patient: young to middle-aged, indoor, inactive or overweight, often in a multi-cat or unsettled home.
  • Classic signs: hematuria, pollakiuria, stranguria and periuria; signs usually resolve in 2 to 7 days with or without treatment but often recur.
  • Zoonotic or reportable: no.

What's inside

11 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Prognosis
  9. Quick review
  10. Test yourself
  11. References
The full guide also has 4 tables, 3 self-test questions and 6 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Idiopathic cystitis on the NavleExam blog.

More guides

Feline · Urinary