Members' NAVLE study guide

Feline GI Lymphoma: Small vs Large Cell | NAVLE Guide

1,628 words 7 min read 1 figure Reviewed November 14, 2026

Lymphoma is the most common gastrointestinal tumour of cats. It splits into two diseases that behave very differently: a slow low-grade (small cell) form that responds to oral drugs, and a fast high-grade (large cell) form that needs multidrug chemotherapy. The practical difficulty is separating low-grade lymphoma from inflammatory bowel disease, which share signs and ultrasound findings.

Key facts

Gastrointestinal lymphoma (small cell or large cell) at a glance
  • Species and system: cat, GI tract (mainly small intestine).
  • Signalment: older cats, typically 10 to 12 years; Siamese cats are predisposed.
  • Low-grade (small cell): mostly mucosal, T-cell, small intestine; chronic weight loss and vomiting.
  • High-grade (large cell): T or B cell, often forms masses; acute illness.
  • Classic presentation: weight loss, vomiting and diarrhoea over months in an older cat, with thickened bowel loops.
  • Zoonotic or reportable: no.

What's inside

11 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Prognosis
  9. Quick review
  10. Test yourself
  11. References
The full guide also has 4 tables, 1 figure, 3 self-test questions and 10 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Gastrointestinal lymphoma (small cell or large cell) on the NavleExam blog.

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