Members' NAVLE study guide

Canine Skin Tumors: MCT, Lipoma, SCC

3,700 words 14 min read 3 figures Reviewed November 11, 2026

Lumps on the skin are among the commonest reasons a dog sees a veterinarian, and the same-looking nodule can be a harmless fatty mass, a self-resolving histiocytoma or a mast cell tumor that needs wide surgery. This guide covers the four groups the NAVLE returns to most: cutaneous mast cell tumors, lipomas, squamous cell carcinoma and histiocytic tumors. The common thread is simple: aspirate every mass before you cut, because the cytology decides the operation.

Key facts

Skin tumors (cutaneous mast cell tumor, lipoma, squamous cell carcinoma, histiocytic sarcoma, etc.) at a glance
  • Species and system: dog; integumentary system (skin and subcutis).
  • Mast cell tumor (MCT): the most common malignant skin tumor of dogs; behaviour ranges from cured by surgery to fatal; histamine release causes Darier's sign and gastroduodenal ulcers.
  • Lipoma: benign tumor of mature fat in older, heavier dogs; the infiltrative variant invades muscle and fascia.
  • Squamous cell carcinoma (SCC): sun-induced on white, thin-haired ventral skin; a separate subungual form attacks the third phalanx of dark-coated large breeds.
  • Histiocytic tumors: histiocytoma ("button tumor" of young dogs, regresses on its own) at one end, histiocytic sarcoma (Bernese Mountain Dogs, Flat-coated Retrievers) at the other.
  • Not zoonotic and not reportable.

What's inside

12 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Differential diagnoses
  7. Treatment and management
  8. Prevention, control and public health
  9. Prognosis
  10. Quick review
  11. Test yourself
  12. References
The full guide also has 4 tables, 3 figures, 3 self-test questions and 27 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Skin tumors (cutaneous mast cell tumor, lipoma, squamous cell carcinoma, histiocytic sarcoma, etc.) on the NavleExam blog.

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Canine · Integumentary