Members' NAVLE study guide

Canine Lymphadenopathy: Work-up and Causes

3,492 words 13 min read 3 figures Reviewed November 10, 2026

Lymphadenopathy means enlarged or otherwise abnormal lymph nodes. It is a physical examination finding, not a diagnosis: the cause ranges from a harmless reaction to a skin infection, through tick-borne and fungal disease, to lymphoma. In dogs, the question the NAVLE keeps asking is simple: which node do you aspirate, what does the cytology mean, and what must you not do (give steroids) before you have an answer?

Key facts

Lymphadenopathy at a glance
  • Species: dog.
  • System: hemic and lymphatic.
  • Four basic causes: reactive hyperplasia, lymphadenitis (inflammation or infection in the node), lymphoma, and metastatic neoplasia.
  • Classic presentation: a middle-aged dog that feels well, with firm, painless, symmetrically enlarged peripheral nodes: think multicentric lymphoma.
  • Key first test: fine-needle aspiration (FNA) and cytology of an enlarged prescapular or popliteal node.
  • Pattern matters: one node or one region suggests a local problem in the area it drains; generalized enlargement suggests systemic disease.
  • Zoonotic or reportable: lymphadenopathy itself is neither, but some causes are zoonotic (Leishmania infantum; Ehrlichia chaffeensis and E. ewingii via ticks) or carry a needle-stick risk (Blastomyces).

What's inside

13 sections in the full guide
  1. Key facts
  2. How the NAVLE tests this
  3. Cause and pathophysiology
  4. Clinical signs
  5. Diagnosis
  6. Major causes in more detail
  7. Differential diagnoses
  8. Treatment and management
  9. Prevention, control and public health
  10. Prognosis
  11. Quick review
  12. Test yourself
  13. References
The full guide also has 9 tables, 3 figures, 3 self-test questions and 17 references, available to NAVLE members.

Read the full study guide

The full guide is part of every NAVLE plan, with diagnosis and treatment tables, figures, a quick review and self-test questions. Start a free trial to try the question bank, or log in if you are already a member.

Read the free overview article A shorter, free article on Lymphadenopathy on the NavleExam blog.

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Canine · Hemic/Lymphatic