Primate Rubeola Study Guide
Overview and Clinical Importance
Rubeola (measles) is a highly contagious viral disease caused by a morbillivirus of the family Paramyxoviridae. While primarily a human disease, rubeola poses a significant threat to nonhuman primates (NHPs) in captivity, laboratory, and zoo settings. Transmission occurs through human-to-primate contact, with humans serving as the natural reservoir. This is a critical zoonotic disease that can cause epizootic outbreaks with high morbidity and mortality in primate colonies.
Etiology and Pathophysiology
Viral Characteristics
Causative Agent: Measles virus (MV), genus Morbillivirus, family Paramyxoviridae
Viral Structure: Enveloped, single-stranded negative-sense RNA virus with two key receptors:
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