Canine Granulomatous Meningoencephalitis (GME) Study Guide
Overview and Clinical Importance
Granulomatous meningoencephalomyelitis (GME) is an idiopathic, non-suppurative inflammatory disease of the central nervous system (CNS) in dogs. It is characterized by perivascular accumulation of mononuclear cells (primarily macrophages and lymphocytes) forming granulomatous lesions within the brain and/or spinal cord. GME is the second most common inflammatory CNS disease in dogs after canine distemper virus encephalitis, accounting for 5-25% of all CNS disorders.
The disease predominantly affects young to middle-aged (4-8 years), small breed dogs, with a potential female predisposition. The etiology remains unknown, though an immune-mediated pathogenesis is strongly suspected. Without treatment, GME is typically progressive and fatal.
Etiology and Pathogenesis
The exact etiology of GME remains unknown (idiopathic). However, several pathogenic mechanisms have been proposed:
You've been studying hard
Create a free account to keep reading
Free accounts get 5 articles/day + daily practice questionJoin vet students already studying with NavleExam.
No credit card needed — free account takes 30 seconds.
Create Free Account — Keep Reading Already have an account? Log inNo spam. One question per day. Unsubscribe anytime.
Take the free NAVLE practice exam
50 exam-style questions across the NAVLE species. See your score as soon as you finish, then get the full answer key with explanations by email. No payment, no account.
Start the free exam →