NAVLE Gastrointestinal and Digestive

Equine Rotavirus Study Guide

Equine rotavirus (ERV) is the most common cause of infectious diarrhea in foals worldwide and represents a high-yield topic for the NAVLE.

Overview and Clinical Importance

Equine rotavirus (ERV) is the most common cause of infectious diarrhea in foals worldwide and represents a high-yield topic for the NAVLE. This double-stranded RNA virus of the family Reoviridae causes significant morbidity on breeding farms, with up to 50% of foals contracting the virus and morbidity rates exceeding 70% during outbreaks. While mortality is typically low (less than 1% with appropriate treatment), the economic impact is substantial due to intensive supportive care requirements, labor costs, and biosecurity measures.

The virus primarily affects foals less than 6 months of age, with the most severe disease occurring in neonates under 2 weeks old. In 2021, a novel Equine Rotavirus Group B (ERVB) was identified in Kentucky, expanding our understanding beyond the traditionally recognized Group A rotaviruses (ERVA). This discovery has significant implications for diagnosis and prevention strategies.

Feature Description
Genome Double-stranded RNA, 11 segments encoding 6 structural and 6 non-structural proteins
Structure Non-enveloped, icosahedral, triple-layered capsid (70-80 nm diameter)
Key Proteins VP7 (G-type) and VP4 (P-type) - outer capsid, elicit neutralizing antibodies; VP6 - middle layer, basis for group classification
Enterotoxin NSP4 - viral enterotoxin causing secretory diarrhea via chloride channel activation
Environmental Stability Highly stable; survives up to 9 months in environment; resistant to pH 3-7; resistant to many common disinfectants

Etiology and Classification

Viral Characteristics

Rotaviruses belong to the genus Rotavirus within the family Reoviridae. The name derives from the Latin word "rota" (wheel) due to the characteristic wheel-like appearance under electron microscopy. Key structural features include:

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