Canine Immune-Mediated Diseases Study Guide
Overview and Clinical Importance
Immune-mediated diseases of the hemic and lymphatic system represent a significant category of autoimmune disorders frequently encountered in canine practice. These conditions occur when the immune system erroneously targets normal blood components for destruction. The most clinically important immune-mediated hematologic diseases in dogs include Immune-Mediated Hemolytic Anemia (IMHA), Immune-Mediated Thrombocytopenia (ITP), and Evans Syndrome (the concurrent presentation of both conditions). These diseases carry significant morbidity and mortality, with IMHA mortality rates historically ranging from 30-70% despite aggressive therapy.
Immune-Mediated Hemolytic Anemia (IMHA)
Definition and Classification
IMHA is an autoimmune disease characterized by premature destruction of red blood cells (RBCs) due to antibody-mediated mechanisms. It is the most common autoimmune disease in dogs and represents a classic example of a Type II (cytotoxic) hypersensitivity reaction.
Pathophysiology
In IMHA, antibodies (primarily IgG or IgM) bind to antigens on the RBC surface, leading to cell destruction through two primary mechanisms:
You've been studying hard
Create a free account to keep reading
Free accounts get 5 articles/day + daily practice questionJoin 14,000+ vet students already studying with NavleExam.
No credit card needed — free account takes 30 seconds.
Create Free Account — Keep Reading Already have an account? Log inNo spam. One question per day. Unsubscribe anytime.