Bovine Ionophore Toxicosis Study Guide
Overview and Clinical Importance
Ionophore toxicosis is a dose-dependent toxic syndrome caused by excessive ingestion of polyether ionophore antibiotics, most commonly monensin (Rumensin), lasalocid (Bovatec), or laidlomycin propionate (Cattlyst). These compounds are widely used in beef and dairy cattle production for improved feed efficiency, growth promotion, and coccidiosis prevention and control.
Ionophores are lipid-soluble molecules produced by Streptomyces species that transport ions across cell membranes, disrupting normal ionic gradients. While safe at recommended doses, toxicosis occurs when cattle ingest excessive amounts due to feed mixing errors, incorrect product selection, or concurrent use with certain antibiotics that inhibit ionophore metabolism.
Ionophores: Background and Approved Uses
Approved Ionophores for Cattle in the United States
Normal Uses and Benefits in Cattle
Approved indications for monensin in beef cattle:
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