BCSE Pharmacology

Endocrine Drugs – BCSE Study Guide

Endocrine pharmacology is essential for BCSE success, covering drugs that treat some of the most common conditions in veterinary practice.

Overview and Clinical Importance

Endocrine pharmacology is essential for BCSE success, covering drugs that treat some of the most common conditions in veterinary practice. This guide covers four major drug categories: insulin and oral hypoglycemics for diabetes management, thyroid drugs for hypo- and hyperthyroidism, corticosteroids for inflammation and immune suppression, and reproductive hormones for breeding management and pregnancy control. Understanding species differences in drug metabolism and clinical applications is crucial for exam success.

High-YieldEndocrine drugs appear frequently in BCSE questions due to the high prevalence of diabetes, thyroid disease, and the widespread use of corticosteroids. Pay special attention to species-specific dosing, especially the key difference between prednisone and prednisolone in cats.
Insulin Type Onset (hr) Peak (hr) Duration (hr) Species Use
Regular (Crystalline) 0.5-1.5 2-4 4-6 DKA emergencies
NPH (Humulin N) 1-2 4-8 8-14 Dogs (1st line)
Lente (Vetsulin) 1-2 4-10 8-14 Dogs (FDA approved)
PZI (ProZinc) 1-3 5-7 8-24 Cats and Dogs (FDA approved)
Glargine (Lantus) 2-4 No peak 12-24 Cats (high remission)
Detemir (Levemir) 2-4 No peak 12-24+ Cats and Dogs (potent)
Drug Mechanism Dose Notes
Glipizide Sulfonylurea - stimulates pancreatic beta cell insulin secretion 2.5 mg/cat PO q12h Cats only. Requires functional beta cells.
Acarbose Alpha-glucosidase inhibitor - delays intestinal glucose absorption 12.5-25 mg/animal PO with meals Adjunctive. GI side effects common.
Velagliflozin (Senvelgo) SGLT2 inhibitor - increases renal glucose excretion 1 mg/kg PO once daily FDA approved for cats. NOT for insulin-treated cats.

Section 1: Insulin and Oral Hypoglycemics

Diabetes Mellitus Overview

Diabetes mellitus is a common endocrine disease in dogs and cats characterized by persistent hyperglycemia due to relative or absolute insulin deficiency. Dogs typically develop Type 1 (insulin-dependent) diabetes requiring lifelong insulin therapy. Cats more commonly develop Type 2 (non-insulin-dependent) diabetes and may achieve remission with appropriate treatment. Clinical signs include polyuria, polydipsia, polyphagia, and weight loss.

MEMORY AID - The 4 Ps of Diabetes

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